- 中文名称
JAK3抑制剂IV；3-[（1-甲基乙基）（苯基甲基）氨基] -1-（2-萘基）-1-丙酮，一盐酸盐
- 英文名字
- JAK3 Inhibitor IV; 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride
- 供应商
- 开曼生物
- 产品货号
- 16729-1
- 产品报价
- ￥1/1mg
- 产品说明书
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- 背景资料
- Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 ?M, respectively).{27341} In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively).{22726} It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.{27341,22726}
- 产品描述
- An inhibitor of JAK3 (IC50 = 79 nM); also inhibits the transglutaminases TGM2 and Factor XIIIa (IC50s= 10 and 25 nM, respectively) in the absence of dithiothreitol; breaks down in neutral buffer to form ZM 449829
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