S-(4-nitrobenzyl)-6-thioinosine is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human, respectively).{26791,26792} It blocks adenosine flux across the plasma membrane, thereby potentiating the interaction of extracellular adenosine with purinoreceptors, which can affect cardiac signaling associated with adenosine.{26792}
产品描述
A nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human, respectively); blocks adenosine uptake, thereby potentiating the interaction of extracellular adenosine with purinoreceptors