AGK2 (Item No. 13145) is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.{17495,16624} AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group.{17495} AGK7 has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3.{17495}
产品描述
An inactive control to be used in experiments with AGK2; has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3