PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.{26247} It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.{26247} The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).{26246}
产品描述
A synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM)