This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
应用类型
IHC
免疫原
Fusion protein corresponding to a region derived from internal residues of human serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
