This gene encodes an enzyme that catalyzes the hydrolysisnof adenosine to inosine. Various mutations have been described fornthis gene and have been linked to human diseases. Deficiency innthis enzyme causes a form of severe combined immunodeficiencyndisease (SCID), in which there is dysfunction of both B and Tnlymphocytes with impaired cellular immunity and decreasednproduction of immunoglobulins, whereas elevated levels of thisnenzyme have been associated with congenital hemolytic anemia.
应用类型
WB,FCM
免疫原
This ADA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA.
