EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that
are encoded by the anhidrotic ectodermal dysplasia (EDA) gene.
Mutations in EDA give rise to a clinical syndrome characterized by
loss of hair, sweat glands, and teeth. The protein encoded by this
gene specifically binds to EDA-A2 isoform. This protein is a type
III transmembrane protein of the TNFR (tumor necrosis factor
receptor) superfamily, and contains 3 cysteine-rich repeats and a
single transmembrane domain but lacks an N-terminal signal peptide.
Multiple alternatively spliced transcript variants have been found
for this gene, but some variants lack sufficient support. [provided
by RefSeq].
