中文名称

N-油酰基乙醇胺

英文名字

N-Oleoylethanolamine

供应商

Matreya

产品货号

1751-100

产品报价

￥询价/100mg

产品说明书

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购买方式

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产品新闻

背景资料

N-Oleoylethanolamine is a naturally occurring acylethanolamide that has been shown to have many biological functions. N-Oleoylethanolamine has been shown to be an efficacious inhibitor of acid ceramidase as well as an inhibitor of glucosylation of natural ceramides.1 It is specifically an inhibitor of the acid ceramidase found in human kidney and cerebellum with an IC50 of approximately 500uM. Farber’s disease is characterized by a lack of acid ceramidase activity and N-oleoylethanolamine can be used to study aspects of this disease. Whereas the inhibitor D-MAPP potently inhibits alkaline ceramidase (IC50 approximately 5uM) N-oleoylethanolamine shows only slight inhibitory characteristics towards this ceramidase.2 N-Oleoylethanolamine is chemically related to the endocannabinoid anandamide, although it is not a cannabinoid itself. It is produced, during feeding, in the small-intestinal enterocytes from oleic acid and phosphatidylethanolamine and acts as a satiety signal (by engaging peroxisome proliferator-activated receptors) and alters gastrointestinal motility. The levels of N-oleoylethanolamine are low during food deprivation (which activates a hunger signal) and normalize with food intake (which activates a satiety, but not a satiation, signal through sensory afferent neurons). It has been shown to reduce weight gain in rats and mice and has been suggested as a tool to combat obesity, diabetes, and eating disorders.3 N-Oleoylethanolamine is also released during sleep deprivation and it is thought that it may act as an endogenous neuroprotective signal.4 Other functions of N-oleoylethanolamine include altering peripheral lipid metabolism, inhibiting gastric emptying, inhibiting insulin metabolic and mitogenic signaling, enhancing memory consolidation, and altering stress responses.

产品描述

Activity: acid ceramidase inhibitor|NOE

产品形式

该N-油酰基乙醇胺产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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