The α2δ1 protein is an auxiliary subunit of the CaV (voltage dependent calcium) channel multimer complex. Four α2δ isoforms were identified in mammalian genoms and they share some sequence as well as structure homology. The protein product of the gene encoding α2δ is complex, it includes two separated proteins the extracellular α2 linked by disulfide bridges to the membrane spanning (single transmembrane helix) δ subunit. α2δ1 subunit is highly expressed in skeletal muscle and brain. Its expression along with a pore forming CaV α1 subunit, result in larger CaV currents, probably due to improved trafficking of the α1 subunit to the plasma membrane. α2δ1 subunit was shown to be the target of the antiepileptic and anelgestic drug gabapentin.
应用类型
经验证,该抗体可应用于IC、LCI、WB等实验应用,也可用于IFC、IH、IP等实验。
免疫原
CaVAlpha2Delta-1 (胞外)抗体的免疫原肽段为EPFPSAVTIKSWVDK(C)。此免疫原序列来源于27-41 of rabbit α2δ1 precursor) (Accession编号为P13806)。胞外, N端