The α2B-Adrenoceptor has a distinct pattern of expression within the brain, liver lung and kidney, and recent studies using the knock out mouse system have shown that disruption of this receptor indeed affects mouse viability, blood pressure responses to α2-Adrenoceptors agonists3 and the hypertensive response to salt loading.n Like the α2A-Adrenoceptor subtype, the α2B-Adrenoceptor undergoes short term agonist promoted desensitization. This desensitization is due to the phosphorylation of the receptor by G-protein coupled receptor kinases (GRKs) which ultimately promotes uncoupling of the receptor from the G-protein subunit