4-氨基萘（25克）-4-Aminopyridine-生化试剂-艾美捷科技有限公司

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背景资料: 4-Aminopyridine (4-AP) is a non-selective Kv channel blocker, which can block a wide variety of Kv channels with different state dependences. Therefore, in search for clues for the structural determinants of Kvchannels that are important for the state dependences of drug-channel interactions, 4-AP serves as a useful tool. For example, it blocks Kv2.1 and Kv3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv1.1 and Kv1.2 channels are blocked by 4-AP with IC50 of 147 µM and 230 µM, respectively, in CHO cells.Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, characterized by axonal conduction block. 4-AP has been tested as a symptomatic treatment in patients with MS based on the clinical rationale that neurologic function could be improved by overcoming conduction block in demyelinated axons present in MS lesions. Indeed, 4-AP restored conduction in experimentally demyelinated nerves in the peripheral nervous system. In addition, 4-AP increased presynaptic action potential duration and amplitude leading to enhanced transmitter release .

产品形式: Voltage-gated K+ channels (Kv) play an important role in number of different aspects of the electrical responses of the nervous system. Their activity determines the frequency of action potential and the shape of the action potential waveform. Furthermore, Kv channels may regulate the excitability of individual neurons, and may control the strength of synaptic contacts between neurons.

保存建议: 艾美捷为您提供的Alonmone Labs原装进口的4-Aminopyridine (25 g)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

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